CMS has opened the application period for physician practices interested in participating in its new primary care model, Comprehensive Primary Care Plus (CPC+), which is intended to improve how primary care is delivered and reimbursed. CMS also announced that the following 14 regions have been selected to participate in CPC+ (statewide unless otherwise noted): Arkansas; Colorado; Hawaii; Kansas and Missouri (Greater Kansas City Region); Michigan; Montana; New Jersey; New York (North Hudson-Capital Region); Ohio (Statewide and Northern Kentucky Region); Oklahoma; Oregon; Pennsylvania (Greater Philadelphia Region); Rhode Island; and Tennessee. Eligible practices in these regions may apply to participate between August 1 and September 15, 2016. CMS estimates that up to 5,000 primary care practices serving 3.5 million beneficiaries may participate in CPC+.  CMS plans a series of educational calls to support participation in the model.