The Patient-Centered Outcomes Research Institute (PCORI) was established by the ACA to support federal comparative effectiveness research efforts. PCORI is seeking nominees for four new advisory panels to make non-binding recommendations to assist PCORI in identifying research priorities and refining its agenda. The advisory panels will focus on addressing disparities; assessing prevention, diagnosis, and treatment options; improving healthcare systems; and patient engagement. The panels will be comprised of patients, caregivers, clinicians, researchers, other healthcare stakeholders, and the general public.