The Patient-Centered Outcomes Research Institute (PCORI) is seeking comments on its draft Methodology Report, proposing standards for the conduct of patient-centered outcomes research.  The report covers, among other things, the rationale for standards for patient-centeredness, prioritizing topics for research; choosing a study design; and for designing, conducting, and reporting research (including standards for adaptive and Bayesian trial designs, registries, and diagnostic tests).  The report also highlights what PCORI characterizes as gaps in evidence that should be addressed by PCORI’s program of methodological research.  Comments will be accepted until September 14, 2012.