The Office for Human Research Protections (OHRP) within the Department of Health and Human Services (HHS) has released “Guidance on IRB Approval of Research with Conditions,” which is OHRP’s first formal guidance on this topic. OHRP also released related “Guidance on Continuing Review.” Both documents are intended primarily for IRBs, investigators, HHS funding agencies, and others that may be responsible for the review, conduct, or oversight of human subject research conducted or supported by HHS.