The Agency for Healthcare Research and Quality (AHRQ) Effective Health Care Program is soliciting applications for a total of $100 million in Recovery Act funding for AHRQ Clinical and Health Outcomes Initiative in Comparative Effectiveness Grants. The purpose of the grants is to conduct large projects in comparative effectiveness aimed at generating new knowledge to help inform decision making in priority areas of clinical care. Research priorities highlighted in the funding announcement include: arthritis and non-traumatic joint disorders; cancer; cardiovascular disease; dementia; depression and other mental health disorders; developmental delays, attention-deficit hyperactivity disorder and autism; diabetes mellitus; functional limitations and disability; infectious diseases including HIV/AIDS; obesity; peptic ulcer disease and dyspepsia; pregnancy including pre-term birth; pulmonary disease/asthma; and substance abuse. Letters of intent are due November 18, 2009.