The Medicare Evidence Development & Coverage Advisory Committee (MedCAC) is meeting on Wednesday, March 18, 2009 to focus on the use of Bayesian statistics to interpret evidence in making coverage decisions. Bayesian analysis is a statistical technique in which prior evidence is used to update or to newly infer the probability that a hypothesis may be true. The meeting will introduce Bayesian concepts, contrast Bayesian approaches with frequentist approaches, and provide examples of using Bayesian techniques for meta-analyses. CMS encourages the participation of organizations with expertise in Bayesian statistics, meta-analyses, and clinical trial design and analyses.