The HHS Office of Inspector General (OIG) has released a report comparing Medicare prescription drug average sales prices (ASPs) and average manufacturer prices (AMPs) for the fourth quarter of 2007. This is the OIG’s first pricing comparison since CMS implemented a revised volume-weighted ASP payment methodology mandated by the Medicare, Medicaid, and SCHIP Extension Act of 2007. Using CMS’s revised ASP payment methodology, the OIG identified 12 of 285 drug codes with ASPs that exceeded AMPs by at least 5 percent in the fourth quarter of 2007.